The game guide confirms via lack of being noted, things that aren’t in the game.
The card list confirms that the card we call “Crystron Glassfiber” isn’t it (the powerful Link 2 for Synchro Summoning and Tuners).
Also, the “Valkyrie” cards from “Shadows in Valhalla” aren’t in.
Also while you can play through Duels based on the first 3 Duels of VRAINS…
It doesn’t have much if any major Story Mode, instead those being confined to the first 5 series.